l{"id":1266143,"date":"2023-08-23T00:00:56","date_gmt":"2023-08-22T23:00:56","guid":{"rendered":"https:\/\/www.businesstelegraph.co.uk\/how-did-surgeons-carry-out-britains-first-womb-transplant\/"},"modified":"2023-08-23T00:00:56","modified_gmt":"2023-08-22T23:00:56","slug":"how-did-surgeons-carry-out-britains-first-womb-transplant","status":"publish","type":"post","link":"https:\/\/www.businesstelegraph.co.uk\/how-did-surgeons-carry-out-britains-first-womb-transplant\/","title":{"rendered":"How did surgeons carry out Britain\u2019s first womb transplant?"},"content":{"rendered":"<p> <script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- newscabal uk text -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:inline-block;width:728px;height:90px\"\r\n     data-ad-client=\"ca-pub-8162386273903324\"\r\n     data-ad-slot=\"3688094655\"><\/ins>\r\n<script>\r\n(adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><img decoding=\"async\" src=\"https:\/\/www.businesstelegraph.co.uk\/wp-content\/uploads\/2023\/08\/How-did-surgeons-carry-out-Britains-first-womb-transplant.jpg\" \/><\/p>\n<div id=\"main\">\n<div class=\"sc-1230l3a-0 dZnGWB newsletter-component sc-12cegbh-0 bWkrIL\" data-newsletter-key=\"receiveindylifestyle\">\n<div class=\"sc-tuvb20-0 iXqBVm\">\n<div class=\"sc-vbc9ga-0 gtQfcL sc-vbc9ga-4 iZTbff\">\n<p><h3 data-nosnippet=\"\" class=\"sc-vbc9ga-1 vcDDl\">Stay ahead of the trend in fashion and beyond with our free weekly Lifestyle Edit newsletter<\/h3>\n<h3 data-nosnippet=\"\" class=\"sc-vbc9ga-2 fKvizi\">Stay ahead of the trend in fashion and beyond with our free weekly Lifestyle Edit newsletter <\/h3>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>Surgeons worked all day and into the night to ensure Britain\u2019s first womb transplant went smoothly.<\/p>\n<p>Its success is down to meticulous research, years of sharing knowledge between experts around the globe, and the hard work and dedication of doctors Professor Richard Smith, from Imperial College London, and Isabel Quiroga, from the Oxford Transplant Centre.<\/p>\n<p>Around 50 babies have been born worldwide as a result of womb transplants, which give women missing a functioning uterus a chance to have a baby.<\/p>\n<p>In the first UK case, the operation to remove the womb from the recipient\u2019s 40-year-old sister lasted eight hours and 12 minutes, with surgeons leaving her ovaries behind to prevent pushing her into early menopause.<\/p>\n<p>One hour earlier, surgeons began operating on the 34-year-old recipient, preparing her body to receive the donated organ. This operation lasted nine hours and 20 minutes, with the surgical team experiencing some difficulties including a higher-than-expected blood loss of two litres.<\/p>\n<p>However, after just 10 days, the recipient was well enough to leave the hospital and has continued to have a good recovery.<\/p>\n<p>She is also having regular periods, which shows the womb is working well.<\/p>\n<figure class=\"sc-482ou5-0 kxcXjT image align-none\"><figcaption class=\"sc-124m7nc-0 sc-124m7nc-2 gMJino cfojIF caption\">\n<div class=\"sc-482ou5-2 fVUzYC\">\n<p>The scene on a Sunday in February as surgeons carried out Britain\u2019s first womb transplant<\/p>\n<\/div>\n<p> (PA)<\/p>\n<\/figcaption><\/figure>\n<p>Her sister was discharged five days after her donor operation and has also made a good recovery.<\/p>\n<p>Removing a womb is a similar operation to a radical hysterectomy, according to Prof Smith, who as well as being a gynaecological surgeon is the clinical lead at the charity Womb Transplant UK.<\/p>\n<p>He and Miss Quiroga led the team of more than 30 staff who worked on the transplant one Sunday in February.<\/p>\n<p>Prof Smith and Miss Quiroga removed the older sister\u2019s womb, cervix and fallopian tubes, plus crucial blood vessels around the organ.<\/p>\n<p>The main vessels are the uterine arteries running into the womb, but the surgeons also aimed to collect some of the larger internal vessels that lead into the smaller branch of the womb.<\/p>\n<p>Prof Smith said surgeons doing these operations have to retrieve veins involved in the drainage of the womb.<\/p>\n<p>\u201cOne of the amazing things is that my surgical skill-mix as a cancer surgeon is to remove organs with a margin of normal tissue, while sealing the vessels as I go,\u201d he said.<\/p>\n<p>\u201cTransplant surgical skills are different \u2013 that is to remove a normal organ with the best number of non-sealed vessels as you can.<\/p>\n<p>\u201cIsabel and I operate together with no ego \u2013 it just flows backwards and forwards across the table.\u201d<\/p>\n<p>He added: \u201cThe day itself was truly humbling. We turned up at 7am at the Churchill transplant centre with the donor and the recipient families, then we went into a pre-op huddle.<\/p>\n<p>Those in the huddle included surgeons, nurses, anaesthetists and technicians.<\/p>\n<p>Prof Smith and Miss Quiroga worked to remove the womb, before the organ was prepared for transplantation by a \u201cback table\u201d team.<\/p>\n<p>\u201cThis was an organ which had a very, very unusual blood supply,\u201d Prof Smith said.<\/p>\n<p>\u201cIn fact, it had a set of blood vessels which I\u2019ve never seen in my entire career. They made my dissection a bit harder than it might have been, but we got there.\u201d<\/p>\n<p>In the theatre next door, one hour before the retrieval of the womb was completed, surgeons began to operate on the donor\u2019s younger sister to enable her to receive the womb.<\/p>\n<p>Prof Smith and Miss Quiroga switched from donor to recipient and Prof Smith removed the vestiges of the underdeveloped womb the recipient was born with.<\/p>\n<p>Meanwhile, the organ was packed and transported between the two theatres under sterile conditions to prevent contamination. A sterile bag with a cold perfusion solution contained the womb, which was then placed into a container with ice.<\/p>\n<p>During surgery, ligaments attached to the womb were attached to the recipient to help the womb stay in a relatively fixed place so it does not move around the pelvis.<\/p>\n<p>The most important part of the transplant operation was the joining of the very small vessels that give the blood supply to the womb.<\/p>\n<p>This was the most delicate and difficult part of the operation and was led by Miss Quiroga. Once all the vessels were connected, the donor\u2019s vaginal cuff \u2013 around a 1cm part \u2013 was stitched into her sister\u2019s vagina.<\/p>\n<p>If and when the recipient is able to complete her family, the womb will be removed six months later to prevent her from needing immunosuppressants for the rest of her life.<\/p>\n<p>Prof Smith said: \u201cWe know that the chance of failure at the point where the uterus goes in \u2013 if you look at the world literature \u2013 is 20 per cent to 25 per cent. And that failure is usually on the basis on sepsis and thrombosis. So technically, we are up to the job, but what happens thereafter can be scary.<\/p>\n<p>\u201cOnce you get to three or four days later, the chance of failure drops to probably less than 10 per cent.<\/p>\n<p>\u201cOnce you get to two weeks \u2013 and at the point where the woman has a period \u2013 the chance of her having a baby at that point is very high and the chance of failure has dropped to low. But those first two weeks \u2013 it\u2019s very scary as a surgeon to watch and wait.\u201d<\/p>\n<p>Biopsies to check the womb was functioning were read in London but then also confirmed by an expert team in the US at Baylor University Medical Centre in Dallas, where other womb transplants have been performed.<\/p>\n<p>Prof Smith said the procedure gives new hope to women born with devastating conditions.<\/p>\n<p>He said: \u201cYou\u2019ve got girls, maybe 14, who have not had periods, they go to the GP and a scan shows there is no uterus. Absolute catastrophe.<\/p>\n<p>\u201cUp until now, there\u2019s been no solution for that, other than adoption or surrogacy&#8230; That\u2019s not the case now. It\u2019s really exciting.\u201d<\/p>\n<p>On whether transgender women may also benefit from the operation, Prof Smith said that was still a long way off. He said the pelvic anatomy, vascular anatomy and shape of the pelvis are different, and there are microbiome issues to overcome.<\/p>\n<p>\u201cMy own sense is if there are transgender transplants that are going to take place, they are many years off. There are an awful lot of steps to go through. My suspicion is a minimum of 10 to 20 years.\u201d<\/p>\n<p>Miss Quiroga said the living donor programme to date in the UK has focused on women with relatives who are willing to give their wombs.<\/p>\n<p>\u201cIt will come to a point where we will have friends or altruistic donors, like we have with many other transplants, but at the moment we\u2019re only focused on people who have come forward with relatives,\u201d she said.<\/p>\n<\/div>\n<p><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block; text-align:center;\"\r\n     data-ad-layout=\"in-article\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-client=\"ca-pub-8162386273903324\"\r\n     data-ad-slot=\"7859258044\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><a href=\"https:\/\/www.independent.co.uk\/life-style\/health-and-families\/health-news\/how-do-surgeons-womb-transplant-uk-b2397336.html\">READ SOURCE<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stay ahead of the trend in fashion and beyond with our free weekly Lifestyle Edit newsletter Stay ahead of the trend in fashion and beyond with our free weekly Lifestyle Edit newsletter Surgeons worked all day and into the night to ensure Britain\u2019s first womb transplant went smoothly. Its success is down to meticulous research, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1266146,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_oct_exclude_from_cache":false,"footnotes":""},"categories":[11],"tags":[],"class_list":["post-1266143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How did surgeons carry out Britain\u2019s first womb transplant? - Business Telegraph<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.independent.co.uk\/life-style\/health-and-families\/health-news\/how-do-surgeons-womb-transplant-uk-b2397336.html\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How did surgeons carry out Britain\u2019s first womb transplant? - Business Telegraph\" \/>\n<meta property=\"og:description\" content=\"Stay ahead of the trend in fashion and beyond with our free weekly Lifestyle Edit newsletter Stay ahead of the trend in fashion and beyond with our free weekly Lifestyle Edit newsletter Surgeons worked all day and into the night to ensure Britain\u2019s first womb transplant went smoothly. 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