Snapping their two-day winning run, equity benchmarks Sensex and Nifty closed in the negative territory on Thursday, tracking losses in index majors Reliance Industries, ITC and HDFC bank amid a weak trend in global markets. The 30-share BSE Sensex declined 388.40 points or 0.59 per cent to settle at 65,151.02. During the day, it fell by 493.32 points or 0.75 per cent to 65,046.10. The NSE Nifty slipped 99.75 points or 0.51 per cent to end at 19,365.25.