Scientists have unveiled the development of an innovative new treatment for addiction to cocaine and its powerful derivative crack – a vaccine.
Dubbed ‘Calixcoca’, the test vaccine, which has shown promising results in trials on animals, triggers an immune response that blocks cocaine and crack from reaching the brain, which researchers hope will help users break the cycle of addiction.
Put simply, addicts would no longer get high from the drug.
The team is based in Brazil, the world’s second-biggest consumer of cocaine.
If the treatment gets regulatory approval, it would be the first time cocaine addiction is treated using a vaccine, said psychiatrist Professor Frederico Garcia, coordinator of the researchers behind the treatment at the Federal University of Minas Gerais.
The project won top prize of €500,000 last week at the Euro Health Innovation awards for Latin American medicine, sponsored by pharmaceutical firm Eurofarma.
The vaccine works by triggering patients’ immune systems to produce antibodies that bind to cocaine molecules in the bloodstream, making them too large to pass into the brain’s mesolimbic system, or ‘reward centre’, where the drug normally stimulates high levels of pleasure-inducing dopamine.
Similar studies have been carried out in the US – the world’s top cocaine consumer, according to the United Nations Office on Drugs and Crime. However, they stalled when clinical trials did not demonstrate sufficient results, among other reasons, Professor Garcia said.
Calixcoca has so far proven effective in testing on animals, producing significant levels of antibodies against cocaine and few side effects.
It also protected rat fetuses against cocaine, researchers found, suggesting it could be used in humans to protect the unborn babies of pregnant addicts.
The vaccine is now set to enter the final stage of trials – testing on humans.
Professor Garcia said Calixcoca could reshape addiction treatment.
‘There’s no specific registered treatment for cocaine and crack addiction. We currently use a combination of psychological counselling, social assistance and rehabilitation, when necessary,’ he said.
Calixcoca could add an important tool to that regimen, helping patients at critical stages of recovery, such as when they leave rehab, he said.
The vaccine is made with chemical compounds designed in the lab, rather than biological ingredients, meaning it would be less expensive to produce than many vaccines, and would not have to be stored at cold temperatures.
But Professor Garcia warned it won’t be a ‘panacea’ that can be administered to anyone.
The exact target group will depend on the outcome of clinical trials, but is theoretically meant to be recovering addicts ‘who are off [cocaine] and want to stay that way’, he said.
The goal is to change what Garcia calls a ‘sad statistic’ – according to the US National Institute on Drug Abuse, one in four regular cocaine users becomes addicted.
And just one in four addicts manages to quit after five years of treatment.
Given the stakes, anticipation around the vaccine is high. More than 3,000 people have contacted Professor Garcia’s team to volunteer to take part in the clinical trials.
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