A new treatment for a rare form of children’s cancer has vastly improved patients chances of survival, a study has found.
The approach combines anti-tumour drugs with chemotherapy to more effectively target neuroblastomas, a rare form of cancer which develops in nerve cells.
By combining anti-angiogenic drugs, which block tumours from forming blood vessels, alongside various chemo drugs, 26% of those treated saw their tumours start to shrink, the clinical trials unit at the University of Birmingham has found.
Patients who received the drug also had better one year progression-free survival rates.
The findings, published in the Journal of Clinical Oncology, saw 160 young people aged between one to 21 randomly selected from 43 hospitals in 11 European countries.
Of those selected, half received the anti-angiogenic drug Bevacizumab on top of conventional therapy.
The parents of Birmingham schoolboy Abdullah Mir, who was given a slim chance of survival after being diagnosed with the rare cancer in 2017, say he owes his life to the clinical trial after two different rounds of chemotherapy drugs failed.
His mother, Bushra Mir, said: ‘It was our last hope. We were desperate because he’d had two lots of chemotherapy that hadn’t shrunk his tumour at all.
‘There were no other options so we signed up thinking that, even if it didn’t benefit Abdullah, it might help someone else.’
After eight months of treatment, 10-year-old Abdullah is now a keen footballer and Manchester United fan who attends Shirelands Technology Primary School in Sandwell.
Simon Gates, Professor of Biostatistics and Clinical Trials at the University of Birmingham – and senior lead author of the paper, said the trial provided ‘very exciting results’.
‘These results hopefully get us closer to finding treatments for children who develop neuroblastomas,’ he added.
‘Currently, the outcomes are really poor for children who get this horrible cancer and so even seemingly small increases in the chance that a patient is going to be able to shrink their tumours is significant.’
Dr Laura Danielson, children and young people’s research lead at Cancer Research UK who part funded the trial, said: ‘These incremental improvements in treatment can make all the difference for cancer patients and it’s fantastic to see that the standard of care across the UK has already been updated based on these results giving children with neuroblastoma more treatment options.
‘Meanwhile, more work is still needed to achieve greater survival and long-term quality of life for children affected by neuroblastoma and this trial is helping to pave the way for studies to better understand the biology of this disease and further efforts to improve outcomes.’
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